|
Well Differentiated Pancreatic Endocrine Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of PTEN and LKB1 synergistically promoted cell proliferation of pNET, attenuated the sensitivity of cells to mTOR inhibitors and enhanced c-Myc expression, which back-regulated PTEN, AKT, mTOR and its downstream effectors.
|
29228674 |
2017 |
|
Von Hippel-Lindau Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Molecular defects have also been identified in syndromes related to the MENs, like Peutz-Jeghers syndrome (PJS) (the STK11/LKB1 gene), and Cowden (CD; the PTEN gene) and von Hippel-Lindau disease (VHLD; the VHL gene).
|
11407658 |
2001 |
|
Vomiting
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Uterine Neoplasms
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Uterine Neoplasms
|
0.100 |
CausalMutation
|
group |
CLINVAR |
|
|
|
|
Uterine Fibroids
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Upregulation of PTEN and LKB1 in concert with negative or low levels of activated Akt, mTOR and S6 indicates that PI3K/Akt/mTOR pathway may not play a significant role in pathogenesis of leiomyoma.
|
27748285 |
2016 |
|
Uterine Cervical Neoplasm
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a detailed analysis of a case of a cervical tumor in a PJS patient showing a large genomic deletion in exon 1 of STK11 without human papillomavirus infection.
|
24490603 |
2014 |
|
Uterine Cervical Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
LKB1 is thus a major cervical tumor suppressor, demonstrating that acquired genetic alterations drive progression of HPV-induced dysplasias to invasive, lethal cancers.
|
19340305 |
2009 |
|
Uterine Cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.
|
27910069 |
2017 |
|
Uterine Cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
The serine/threonine kinase LKB1 has been identified as a potent suppressor of uterine cancer, but the biological modes of action of LKB1 in this context remain incompletely understood.
|
26413869 |
2015 |
|
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
tumor vasculature
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio.
|
26470595 |
2015 |
|
Tumor Promotion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data suggest that LKB1 loss early in ovarian serous tumorigenesis has an integral role in tumor promotion by disrupting apical to basal polarity in the presence of mutated p53 in fallopian tube cells.
|
25798842 |
2016 |
|
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Somatic mutation of the tumor suppressor gene LKB1 occurs frequently in lung cancer where it causes tumor progression and metastasis, but the underlying mechanisms remain mainly unknown.
|
23074285 |
2012 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we have shown that LKB1 suppresses tumor progression by altering gene expression in the tumor microenvironment.
|
26413869 |
2015 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The suppression of MYC by LKB1 controls epithelial organization; therefore, we hypothesize that MYC expression can be increased via wild-type LKB1 loss and promotes tumor progression.
|
24793789 |
2015 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Liver kinase B1 (LKB1) is a newly discovered tumor suppressor gene that plays a role in tumorigenesis and cancer progression.
|
30171989 |
2019 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
LKB1 deficiency increased proliferation and osteoblast differentiation of Ctsk+ periosteal cells, while downregulation of mTORC1 activity, using Raptor genetic mouse model or mTORC1 inhibitor treatment, ameliorated tumor progression of Ctsk-Cre Lkb1fllfl mice.
|
30830877 |
2019 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We propose that LKB1 acts as a safeguard against HPV-stimulated aerobic glycolysis and tumor progression.
|
27546620 |
2017 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Liver kinase B1 (LKB1) functions as a tumor suppressor gene, and loss in the expression of LKB1 contributes to human carcinogenesis and tumor progression.
|
26549522 |
2016 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Downregulation of LKB1 promotes tumor progression and predicts unfavorable prognosis in patients with glioma.
|
28454310 |
2017 |
|
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These results posit LKB1 haploinsufficiency as a risk factor for tumor progression of BRAF(V600E) mutated lung adenomas in human cancer patients.
|
23825589 |
2013 |
|
Tumor Progression
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Recent evidence indicates that LKB1 alterations contribute to cancer progression and metastasis by modulating vascular endothelial growth factor (VEGF) production.
|
25179843 |
2014 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We wondered whether LKB1 loss could be deregulated at the transcriptional level to promote tumor progression and poor outcome in colorectal cancer.
|
24879590 |
2014 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
LKB1 expression was observed to significantly downregulate the accompanying cancer progression, which was verified at the protein level by western blot analysis.
|
24676538 |
2014 |